Carcinoma renal

Metastásico

Categorías de riesgo en carcinoma renal metastásico - El Modelo Motzer MSKCC

- Mekhail TM, Abou-Jawde RM, BouMerhi G, Validation and Extension of the Memorial Sloan-Kettering Prognostic Factors Model for Survival in Patients With Previously Untreated Metastatic Renal Cell Carcinoma. J Clin Oncol 2005 23: 832-841

Tratamientos
1. Bevacizumab + Infterferón

- Escudier B, Pluzanska A, Koralewski P, et al, for the AVOREN Trial investigators. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. The Lancet 2007; 370:2103-2111

2. Sunitinib es superior al interferón en cáncer renal metastásico - Sutent in mRCC

- Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma. N Engl J Med 2007 356: 115-124

3. Sorafenib en carcinoma renal metastásico en segunda línea - TARGET

- Escudier B, Eisen T, Stadler WM, et al, the TARGET Study Group, Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma. N Engl J Med 2007 356: 125-134

4. Temsirolimus en carcinoma renal metastásico de alto riesgo - Global ARCC

- Hudes G, Carducci M, Tomczak P, et al, the Global ARCC Trial, Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma. N Engl J Med 2007 356: 2271-2281

5. Everolimus - RECORD1

- Motzer RJ, Escudier B, Oudard S, et al; RECORD-1 Study Group. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet. 2008 Aug 9;372(9637):449-56.

6. Interleucina 2 de altas dosis IL-2

- Fyfe G, Fisher RI, Rosenberg SA, et al. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol, 1995: 688-696

Boletín técnico 11 - Altas dosis de Interleucina 2 (.doc, 97, 100 kB)

Guías para la administración segura de interleucina 2
- Scwatzentruber D. Guidelines for the safe administration of high-dose interleukin-2. J. Immunother. 2001, 24: 287-293

Tabla de administración segura de interleucina 2

Interleukin 2 - Package insert