Cáncer del pulmón

CARCINOMA BRONCOGÉNICO DE CÉLULAS NO PEQUEÑAS (NSCLC)

QUIMIOTERAPIA EN NSCLC - ADYUVANTE

Meta-análisis en quimioterapia adyuvante para carcinoma del pulmón de células no pequeñas

- LACE Collaboration

- Pignon JP, Tribodet H, Scagliotti GV, et al. Lung Adjuvant Cisplatin Evaluation: A Pooled Analysis by the LACE Collaborative Group. J Clin Oncol 2008 26: 3552-3559

Cisplatino + Vinorelbina para estadíos IB y II - JBR.10

- Winton T, Livingston R, Johnson D, et al, the National Cancer Institute of Canada Clinical Trials Group and the National Cancer Institute of the United States Intergroup JBR.10 Trial Investigators, Vinorelbine plus Cisplatin vs. Observation in Resected Non-Small-Cell Lung Cancer. N Engl J Med 2005 352: 2589-2597


QUIMIOTERAPIA EN NSCLC - PRIMERA LÍNEA

Meta-análisis en quimioterapia para carcinoma del pulmón de células no pequeñas avanzado

NSCLC Meta-Análisis - 2008

- NSCLC Meta-Analyses Collaborative Group, Chemotherapy in Addition to Supportive Care Improves Survival in Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis of Individual Patient Data From 16 Randomized Controlled Trials. J Clin Oncol 2008 26: 4617-4625

"Todas las dupletas basadas en platino son iguales..." - ECOG 1594

- Schiller JH, Harrington D, Belani CP, et al, the Eastern Cooperative Oncology Group, Comparison of Four Chemotherapy Regimens for Advanced Non-Small-Cell Lung Cancer. N Engl J Med 2002 346: 92-98

A lo mejor, Pemetrexed es mejor en adenocarcinoma - PemCisTrial

- Scagliotti GV, Parikh P, von Pawel J, et al. Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non-Small-Cell Lung Cancer. J. Clin. Oncol. Jul 20, 2008; 26: 3543-3551.

Bevacizumab en carcinoma de pulmón de células no pequeñas avanzado - ECOG 4599

- Sandler A, Gray R, Perry M. et al. Paclitaxel-Carboplatin Alone or with Bevacizumab for Non-Small-Cell Lung Cancer. N Engl J Med 2006 355: 2542-2550

QUIMIOTERAPIA EN NSCLC - SEGUNDA LÍNEA

Docetaxel en segunda línea - TAX320

- Fossella FV, DeVore R, Kerr RN, et al. Randomized Phase III Trial of Docetaxel Versus Vinorelbine or Ifosfamide in Patients With Advanced Non-Small-Cell Lung Cancer Previously Treated With Platinum-Containing Chemotherapy Regimens. J Clin Oncol 2000 18: 2354-2362

Pemetrexed es menos tóxico que el docetaxel en segunda línea - Pemetrexed

- Hanna N, Shepherd FA, Fossella FV, et al. Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non-Small-Cell Lung Cancer Previously Treated With Chemotherapy. J Clin Oncol 2004 22: 1589-1597

Erlotinib en segunda línea - BR.21

- Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. the National Cancer Institute of Canada Clinical Trials Group, Erlotinib in Previously Treated Non-Small-Cell Lung Cancer. N Engl J Med 2005 353: 123-132

CARCINOMA DEL PULMÓN DE CÉLULAS PEQUEÑAS (SCLC)

Radioterapia craneal profiláctica en SCLC de estadío extendido - EORTC

- Slotman B, Faivre-Finn C, Kramer G et al, the EORTC Radiation Oncology Group and Lung Cancer Group, Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer. N Engl J Med 2007 357: 664-672